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Snapgene 3.2.11/6/2024 ![]() However, further advance trials such as in vitro and in vivo testing are involved for validation.", Conclusions: This study exhibits the transformations of amino acid in Indonesian B.1.1.7 isolates, and proposes four peptides () from S protein as the candidate for a peptide-based vaccine. Furthermore, the development of in silico cloning using pET plasmid was successfully achieved. Furthermore, various peptides based on the B-cell epitope prediction, allergenicity prediction, toxicity prediction from S protein to generate a vaccine contrary to SARS-CoV-2 were identified. Results: In this study, the changes of amino acid in all seven Indonesian B.1.1.7 isolates were uncovered. Moreover, in silico cloning was developed by using SnapGene v.3.2.1 software. In addition, PEP-FOLD3 web server was utilized to perform peptide modeling, while docking was performed using PatchDock, FireDock, and the PyMOL software. The IEDB was implemented to reveal the linear B-cell epitopes. MEGA X was employed to understand the transformations of amino acid in the S protein and to develop a molecular phylogenetic tree. Methods: The sequences of seven Indonesian B.1.1.7 isolates, Wuhan-Hu- 1 isolate, and WIV04 isolate were extracted from the GISAID EpiCoV and GenBank, NCBI. Aims: To analyze the B-cell epitope conserved region and viroinformatics-based study of the SARS-CoV-2 lineage from Indonesian B.1.1.7 isolates to invent a vaccine nominee for overcoming COVID-19. However, further advance trials such as in vitro and in vivo testing are involved for validation.Ībstract = "Context: SARS-CoV-2, a member of family Coronaviridae and the causative agent of COVID-19, is a virus which is transmitted to human and other mammals. Conclusions: This study exhibits the transformations of amino acid in Indonesian B.1.1.7 isolates, and proposes four peptides ("LTPGDSSSGWTAG", "VRQIAPGQTGKIAD", "ILPDPSKPSKRS", and "KNHTSPDVDLG") from S protein as the candidate for a peptide-based vaccine. Reads terminal service related keys (often RDP related)Īdversaries may collect data stored in the Windows clipboard from users copying information within or between applications.Context: SARS-CoV-2, a member of family Coronaviridae and the causative agent of COVID-19, is a virus which is transmitted to human and other mammals. Remote desktop is a common feature in operating systems. Reads information about supported languagesĪdversaries may attempt to get a listing of services running on remote hosts, including those that may be vulnerable to remote software exploitation.ĭetected increased number of ARP broadcast requests (network device lookup) Process injection is a method of executing arbitrary code in the address space of a separate live process.Īdversaries can use methods of capturing user input for obtaining credentials for ] and information ] that include keylogging and user input field interception.Ĭontains ability to retrieve keyboard strokesĪdversaries may interact with the Windows Registry to gather information about the system, configuration, and installed software. Installs hooks/patches the running process Windows processes often leverage application programming interface (API) functions to perform tasks that require reusable system resources. Opens the Kernel Security Device Driver (KsecDD) of Windows Loadable Kernel Modules (or LKMs) are pieces of code that can be loaded and unloaded into the kernel upon demand.
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